Depigmentation Serum

Skin-lightening cosmetics are generally employed as classical skin lighteners as well as to achieve an even skin tone. An uneven skin tone can occur due to skin inflammation, intensive exposure to the sun, hormone intake or to the natural ageing process of the skin.

A further important factor that can influence skin tone is a so-called hyper pigmentation of the skin, i.e. too strong production of naturally occurring skin pigmentation substances. This reaction can be influenced, or somehow 'have the brakes put on' by using skin-lightening substances.

While in the past substances based on animal derivatives were used a lot, today use of plant-based active substances aimed specifically at lightening the skin on the increase.

PRODUCT DESCRIPTION...

The serum is a new plant-derived skin lightening product. Its efficacy has been proven in in vitro assays and in vivo studies. The serum is created from complex plant extracts as bearberry Arctostaphylos uva-ursi) whose primary mechanism of action is tyrosinase inhibition combined with magnesium ascorbyl phosphate which has an antioxidative and stabilizing effect. For optimum product function and skin protection, an appropriate sunscreen should generally be used in combination with the serum.

Skin lightening cosmetics are used for their general lightening effects and for evening out skin tone. Uneven skin pigmentation may be caused by inflammation, excessive sunlight, hormone treatments, aging process etc. Epidermal pigments are mixtures of the orange phaemelanin and the brown-black eumelanin. The melanogenic pathway leading to these biopolymers starts with the amino acid tyrosine and is under control of the glycosylated tyrosinase. Inhibition of this tyrosinase, which is located in the basal layer of the melanosomes, prevents the formation of the two melanin biopolymers. The serum creates tyrosinase inhibitors through the epidermis of the melanosomes. The efficacy of the serum as a tyrosinase inhibitor has been demonstrated in vitro. In this assay, the formation of dopachrome, an intermediate product of melanogenesis, was determined spectrophotometrically at 475 nm.

The inhibition curve shows that the serum inhibits melanogenesis at low concentrations and can therefore be considered as a very effective tyrosinase inhibitor.

IN VIVO SKIN LIGHTENING STUDY...

A controlled study in 10 female volunteers of Asian descent aged 25 to 50 years was undertaken and showed significant reduction in pigmentation in comparison with other products